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Renate Gorre D-78465
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Series in
MICROSYSTEMS
edited by P. A. Besse, J. Brugger, M. Gijs, R. S. Popovic,
Ph. Renaud
Vol. 19:
Pontus Linderholm
Two-dimensional Microimpedance
Imaging for Cell Culture Monitoring
1st Edition 2006. XXVIII, 252 p.; € 64,00.
ISBN 3-86628-107-2
Three-dimensional
tissue cultures are becoming increasingly prevalent in pharmacological and
biomedical research. Measuring the thickness and permeability of in-vitro
tissue is, however, wrought with difficulties. In this thesis, Linderholm proposes a low-cost technology, based on planar
microelectrodes integrated directly into culture chambers, which allows
creating images of the vertical cross-sections of growing tissue. It is shown
how this imaging technique can be applied to measuring tissue growth, cell
migration and drug-induced permeability changes in the cell membranes. A
substantial part of the work is also devoted to calculating the electric field
using conformal mapping, and modeling the impedance
spectra of four-point measurements.
Pontus Linderholm
received his M.Sc in Engineering Biology from the
University of Linköping, Sweden, in 2001. He joined the Institute of
Microsystems of the EPFL in 2002, where he developed a miniaturized impedance
imaging sensor as part of his PhD work. Linderholm
has coauthored 10 scientific publications, and
currently lives in Stockholm, Sweden.
Keywords: miniaturized impedance
tomography, electrical imaging, cell culture, four-electrode, conformal
mapping, microelectrode, BioMEMS.
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