Selected Readings in Vision and Graphics
edited by Luc Van Gool, Gábor Székely, Markus Gross, Bernt Schiele

Volume 48

Martin von Siebenthal

Analysis and Modelling of Respiratory
Liver Motion using 4DMRI

First edition 2008, 166 pages, € 64,00. ISBN 3-86628-194-3

This thesis describes methods for imaging, analysis, and modelling of respiratory organ motion in order to improve planning and targeting in radiation therapy. To study respiratory motion in detail, a method for time resolved volumetric magnetic resonance imaging (4DMRI) was developed.


The analysis of 4DMRI data from volunteers provided new insights into the intrafraction motion of the liver during free breathing. Simulations of different gating scenarios demonstrated the large targeting errors that can result from intrafraction drifts in gated treatment with external respiratory signals.


In order to improve targeting, we show how to capture the observed motion in a statistical model and how to use this model as prior knowledge together with possibly few patient-specific measurements. The obtained motion data was further used to evaluate the dosimetric impact of respiratory motion in radiation therapy with scanned proton beams.



About the author:


Martin von Siebenthal received his M.Sc. in Electrical Engineering and Information Technology and the ETH Zurich Medal for an outstanding master thesis in 2004. During his doctoral studies he worked at the Computer Vision Laboratory of ETH Zurich as a teaching and research assistant with a focus on imaging and analysis of respiratory organ motion in radiation therapy. He was awarded his Ph.D. (Dr. sc. ETH Zurich) in 2008.



Keywords / Schlagwörter:
Magnetic Resonance Imaging, Organ Motion, Respiration, Breathing, Radiation Therapy, Proton Therapy, 4DMRI, Registration, Statistical Modelling, Respiratory Gating


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